Spyros served as Minister of State for Foreign Economic, Environmental, and Cultural Affairs until 2011. In this capacity, he was responsible for environmental and cultural diplomacy, economic and energy issues, development cooperation, and humanitarian assistance.
He was first elected as a Member of the Hellenic Parliament in 2007 and was re-elected in 2009. During 2007-2009, he served as the Shadow Minister of Environment, Energy, and Planning for the leading opposition party.
Additionally, Spyros is a Senior Associate of the University of Cambridge Institute for Sustainability Leadership (CISL) and acts as an ambassador of the programme in the South-East Europe and East Mediterranean regions. He also teaches in selected programmes of the Institute.
He is the Founder and Director of the Institute for Sustainable Development of the European Public Law Organization (EPLO), which started as a joint initiative between the Cambridge Institute for Sustainability Leadership (CISL) and EPLO. Since November 2019, the Institute is fully incorporated within EPLO, enjoying its status as an International Organization and Permanent Observer of the UN General Assembly.
Furthermore, Spyros serves as a Senior Advisor to the UNEP Mediterranean Action Plan for the Mediterranean Strategy on Sustainable Development 2016-2025, and the Sustainable Consumption and Production Plan (Circular Economy).